2021 NDC/HCPCS Crosswalk


The NDC/HCPCS Crosswalk file provides a list of National Drug Codes (NDC) linked to Level II HCPCS codes, including pricing conversion factors for billable claims submitted to the DME MACs. This crosswalk enables the processing of claims using the NCPDP format. It includes prescription drugs administered in a home setting that are eligible for reimbursement under the DMEPOS benefit.

The PDAC updates the crosswalk monthly to add, revise, or delete NDCs as published in the RED BOOK drug compendium. The prepared NDC/HCPCS Crosswalk files below outline these updates and changes.

For NDC/HCPCS crosswalk questions, view our NDC/HCPCS Crosswalk FAQs and Definitions.

 

December 2021

NDC to HCPCS Crosswalk (Excel, 1114 KB)
NDC to HCPCS Crosswalk (PDF, 2944 KB)
Date Changes (PDF, 12 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 30 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 8 KB)

November 2021

NDC to HCPCS Crosswalk (Excel, 1108 KB)
NDC to HCPCS Crosswalk (PDF, 2929 KB)
Date Changes (PDF, 15 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 29 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 8 KB)

October 2021

NDC to HCPCS Crosswalk (Excel, 1104 KB)
NDC to HCPCS Crosswalk (PDF, 2919 KB)
Date Changes (PDF, 12 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 28 KB)
Records and NDCs Removed (PDF, 39 KB)
Additional Changes (PDF, 8 KB)

September 2021

NDC to HCPCS Crosswalk (Excel, 1106 KB)
NDC to HCPCS Crosswalk (PDF, 2915 KB)
Date Changes (PDF, 48 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 37 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 8 KB)

August 2021

NDC to HCPCS Crosswalk (Excel, 1095 KB)
NDC to HCPCS Crosswalk (PDF, 2891 KB)
Date Changes (PDF, 10 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 26 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 8 KB)

July 2021

NDC to HCPCS Crosswalk (Excel, 1091 KB)
NDC to HCPCS Crosswalk (PDF, 2881 KB)
Date Changes (PDF, 15 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 31 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 8 KB)

June 2021

NDC to HCPCS Crosswalk (Excel, 1087 KB)
NDC to HCPCS Crosswalk (PDF, 2849 KB)
Date Changes (PDF, 13 KB)
Coding Changes (PDF, 8 KB)
Conversion Factor Changes (PDF, 9 KB)
Records and NDCs Added (PDF, 29 KB)
Records and NDCs Removed (PDF, 144 KB)
Additional Changes (PDF, 8 KB)

May 2021

NDC to HCPCS Crosswalk (Excel, 1068 KB)
NDC to HCPCS Crosswalk (PDF, 1247 KB)
Date Changes (PDF, 55 KB)
Coding Changes (PDF, 54 KB)
Conversion Factor Changes (PDF, 57 KB)
Records and NDCs Added (PDF, 58 KB)
Records and NDCs Removed (PDF, 57 KB)
Additional Changes (PDF, 54 KB)

April 2021

NDC to HCPCS Crosswalk (Excel, 1019 KB)
NDC to HCPCS Crosswalk (PDF, 1036 KB)
Date Changes (PDF, 55 KB)
Coding Changes (PDF, 53 KB)
Conversion Factor Changes (PDF, 56 KB)
Records and NDCs Added (PDF, 59 KB)
Records and NDCs Removed (PDF, 57 KB)
Additional Changes (PDF, 54 KB)

March 2021

NDC to HCPCS Crosswalk (Excel, 1014 KB)
NDC to HCPCS Crosswalk (PDF, 1032 KB)
Date Changes (PDF, 55 KB)
Coding Changes (PDF, 53 KB)
Conversion Factor Changes (PDF, 56 KB)
Records and NDCs Added (PDF, 60 KB)
Records and NDCs Removed (PDF, 56 KB)
Additional Changes (PDF, 54 KB)

February 2021

NDC to HCPCS Crosswalk (Excel, 1043 KB)
NDC to HCPCS Crosswalk (PDF, 1203 KB)
Date Changes (PDF, 54 KB)
Coding Changes (PDF, 52 KB)
Conversion Factor Changes (PDF, 55 KB)
Records and NDCs Added (PDF, 59 KB)
Records and NDCs Removed (PDF, 66 KB)
Additional Changes (PDF, 53 KB)

January 2021

NDC to HCPCS Crosswalk (Excel, 1082 KB)
NDC to HCPCS Crosswalk (PDF, 6090 KB)
Date Changes (PDF, 177 KB)
Coding Changes (PDF, 173 KB)
Conversion Factor Changes (PDF, 178 KB)
Records and NDCs Added (PDF, 181 KB)
Records and NDCs Removed (PDF, 205 KB)
Additional Changes (PDF, 175 KB)

Last Updated: 11/30/2021